Billy Gardell decided to stop smoking and drinking altogether and started walking around 30 minutes a day with the Billy Gardell Weight Loss program. He also made changes to Billy Gardell Weight Loss diet. He stopped eating sugary junk food and made it a point to include a lot of lean meat and vegetables in Billy Gardell Weight Loss diet. In 2010, he started taking non-insulin injectable medications. Eventually, he was able to shed over 200 pounds. Today, he looks younger and healthier than ever before.

In late 2009, Gardell married Patty Knight and gave birth to a son, William III. He and Patty have one child together, William IV. The two met while working at a TV show and later married. The child was born in 2003. In an interview published in 2019, Gardell admitted to his weight problem and said he was embarrassed to be overweight. His weight gain was caused by bad habits like smoking and drinking. He said that these bad habits were part of his lifestyle and he was ashamed of them.